Endocrine Abstracts

Objective: To study the impact of HBV related chronic liver disease (CLD) and its treatment with Tenofovir on bone health in Indian subjects.Methods: This cross-sectional study included men between 18 and 60 years and comprised of three groups: Group 1 was treatment naïve HBV-related CLD (n=79), Group 2 – those with HBV-related CLD on tenofovir for at least 1 year duration (n=136), Group 3 – normal age, sex and BMI-matche...

Introduction: B cell lymphoma of brain is a rare form of lymphoma of brain and it presetting as SIADH is very rare. In this case it was very difficult to find the cause for SIADH with all routine tests. Ultimate diagnosis was by histopathology.Case report: 68 year old gentlemen admitted with vomiting found to be hyponatraemic with serum sodium of 122 mmol/litre. He was known to have chronic lymphocytic lymphoma treated with chemotherapy with good remissi...

Introduction: Haemophilia A and B has been associated with increased prevalence of low bone mineral density (BMD). However, no study has so far evaluated the effects of anti-osteoporotic therapy on BMD.Methods/design: The primary endpoint of this prospective study was to estimate the effect of 12-month therapy of oral ibandronate 150 mg/month on BMD in patients with haemophilia A and B. Secondary endpoint was its effect on bone turnover markers (BTM), in...

The tachykinin neurokinin B (NKB) has prominent roles in neuroendocrine function, behaviour and the control of reproductive processes, yet little is known about its evolution, potential splice variants or the manner in which it is processed. Indeed, the cloning of human TAC3 in 2000 revealed a single gene transcript encoding a single precursor and single tachykinin. Here, we deduce the phylogenetic relationship of a family of NKB peptides, and identify novel TAC3...

Identifying the pathogenic pathways involved in complex diseases such as Graves’ disease (GD) has proved challenging. Although several genetic risk factors, including the HLA class II region, CTLA4, PTPN22 and CD25, encode molecules playing key roles in antigen presentation and controlling T cell recognition/signalling, the identification of novel susceptibility loci has the potential to provide further insights into disease pathogenesis. Recently gen...

Background: Diffuse large B-cell lymphoma is the most common non-Hodgkin’s lymphoma (NHL). It can involve extranodal sites in about 30%, but the involvement of endocrine organs is rare (adrenal involvement is estimated<0.2%) and correlates with poor prognosis. In contrast to pituitary metastases from solid tumors, NHL involvement of the anterior lobe of the pituitary is more frequently seen.Case presentation: A 84-year-old woman presented to the...

Abstract: Familial benign hypocalciuric hypercalcemia (FHH) is a rare AD disorder exhibiting benign hypercalcemia, inappropriately normal PTH levels and relative hypocalciuria, thus reflecting partial resistance to the normal effects of extracellular calcium on parathyroid glands and kidneys. We report a 74-year-old women, with no fracture history, with bisphosphonate osteoporosis treatment (2011-present), with HLA B 27 positive ankylosing spondylitis. The clinical exam reveal...

We recently identified a group of neurons in the arcuate nucleus of the mammalian hypothalamus that co-localize three neuropeptides, kisspeptin, neurokinin B and dynorphin, each of which has been shown to play a critical role in the central control of reproduction. Growing evidence suggests that this subpopulation, abbreviated as the ‘KNDy’ subpopulation, plays a key role in mediating hormonal feedback control of GnRH secretion. KNDy cells are a major target for ster...

Introduction: Association between lymphoma and pituitary dysfunction is well documented, though most commonly through mechanism of infiltrative pituitary metastasis, or primary lymphoma of the pituitary, rather than autoimmune lymphocytic hypophysitis. Here we present a highly unusual case whereby investigation into the cause of Diabetes Insipidus with radiological features of lymphocytic hypophysitis, led to diagnosis and cure of Diffuse Large B-cell lymphoma (DLBCL). Diabete...

Introduction: Metformin is effective in reducing cardiovascular mortality, however may decrease vitamin B12 and folate levels, and increase levels of homocysteine. Hyperhomocysteinemia is associated with adverse impact on lipid parameters and renal function. The present study was designed to determine the effect of homocysteine lowering therapy by using group B vitamins and folate supplementations on lipid metabolism especially HDL cholesterol as well as kidney function assess...